image credit: Clostridium difficile, CDC/PHIL #9999 by Janice Carr
Education
Bachelor of Science, 2000
Biology
Florida State University, Tallahasssee FL
Master of Public Health, 2002
Environmental and Occupational Health- Tropical and Communicable Disease
University of South Florida, Tampa FL
Doctor of Philosophy, 2009
Biomedical Science
University of Central Florida, Orlando, FL
Research
Current Research
Gordon State College
Barnesville, Georgia
Current research includes collaboration with Dr. Amanda Duffus who studies disease distribution in amphibian populations. This fall we will be examining the prevalence of Salmonella in local amphibian populations. Georgia is the number one producer of poultry in the United States and we are interested in examining if close proximity to poultry farms influences Salmonella prevalence within wildlife. Students will learn bacterial sampling techniques, laboratory culture methods and molecular diagnostic techniques for the identification of colonized amphibians. Other research interests include microbial selenoprotein synthesis and the transition from aerobic to anaerobic growth in Escherichia coli.
Post-Doctoral Fellowship: 2009-2010
Mercer University School of Medicine
Macon, Georgia
Research focused on toxin-antitoxin (TA) loci in the pathogen Haemophilus influenza. This organism is responsible for otitis media (ear infections). These TA loci are associated with the regulation of stress-induced reversible growth arrest. Research aims included the generation of recombinant strains deficient in three identified TA loci, characterization of these mutant strains under stress conditions and evaluation of the role of TA loci in pathogenesis.
Doctoral Research: 2004-2009
University of Central Florida
Orlando, Florida
Research included characterization of selenoproteins and selenium metabolism in the anaerobic microorganisms Treponema denticola and Clostridium difficile. Studies were focused on targeting selenium metabolism in the development of novel antimicrobial agents and the characterization of C. difficile toxin gene regulation in response to selenium dependent Stickland fermentation of amino acids.
Advising
If you fail to plan, you plan to fail! I am available for advising during office hours at any point during the semester. I am happy to sit down with you and discuss your degree plan. If you need to request an appointment or have specific questions, please contact me via email. Please consult the following links and/or the academic catalog for information regarding specific degree programs.
Associate of Science with a concentration in Biology and Biological Sciences
Bachelor of Science in Biology or Biology with Teacher Certification
Publications
Rosario, S.E. and W.T. Self. 2013. Selenoenzymes and selenium trafficking: an emerging target for therapeutics (book chapter) in Metals in Cells. John Wiley & Sons, Ltd, Chichester, United Kingdom.
Jackson-Rosario, S.E. and W.T. Self. 2010. Targeting selenium metabolism and selenoproteins: Novel avenues for drug discovery. Metallomics 2:112-116
Jackson-Rosario, S., and W. T. Self. 2009. Inhibition of selenium metabolism in the oral pathogen Treponema denticola. J Bacteriol 191:4035-40.
Jackson-Rosario, S., D. Cowart, A. Myers, R. Tarrien, R. L. Levine, R. A. Scott, and W. T. Self. 2009. Auranofin disrupts selenium metabolism in Clostridium difficile by forming a stable Au-Se adduct. J Biol Inorg Chem 14:507-19.
Ganyc, D., Talbot, S., Konate, F., Jackson, S., Schanen, B. Cullen, W., and W.T. Self (2007). Impact of Trivalent Arsenicals on Selenoprotein Synthesis. Environ Health Persp. 115(3):346-353.
Jackson, S., Calos, M., Myers, A., and W.T. Self (2006). Analysis of proline reduction in the nosocomial pathogen Clostridium difficile. J. Bacteriol. 188(24):8487-95.
Peer-Reviewed Abstracts and Meeting Presentations
J.B. Campbell*, S.E. Rosario, and A.L.J. Duffus (2016) Are partial Ranavirus major capsid protein sequences enough for phylogenetic reconstruction? Georgia Academy of Sciences, Gordon State College, April 1 and 2. (Student won an award for this poster)
J.B. Campbell*, A.L.J. Duffus, and S. E. Rosario (2015) Comparing DNA sequence alignment methods for Ranavirus phylogenetic reconstruction. American Society of Microbiologists- Southeast Branch Meeting, Kennesaw, GA, November 13-15.
L. Newman*, Rosario, S.E., Duffus, A.L.J., and C. Lee (2014) Plant DNA Barcoding: An Ongoing Research Project at Gordon State College. Georgia Academy of Sciences, Georgia Regents University, Augusta, GA, March 28-29.
A.L.J. Duffus*, and S.E. Jackson-Rosario (2013) Iridovirus Phylogenetics: Is the Major Capsid Protein Enough? Second International Symposium on Ranaviruses, Knoxville, TN, July 27-28.
C.M. Jackson*, J. Thaeter, A.L.J. Duffus and S. Jackson-Rosario (2012) Iridovirus phyogenetics: is the major capsid protein enough? Annual meeting of the Southeastern Branch of the American Society for Microbiology, Athens, Georgia, October 25th-27th.
S.E. Jackson-Rosario*, D.A. Daines (2010) “The vapBC-1 toxin-antitoxin locus plays a role in the adaptation of nontypeable Haemophilus influenzae to stress” 110th General Meeting of the American Society for Microbiology (ASM), San Diego, California, May 23-27, 2010.
S. E. Jackson-Rosario*, C. Korsvik, A. Myers, R. Tarrien, W. T. Self (2009) “Stickland fermentation and toxin production in Clostridium difficile” 109th General Meeting of the American Society for Microbiology (ASM), Philadelphia, Pennsylvania, May 17-21, 2009. Poster B-121.
S.E. Jackson-Rosario and W. T. Self* (2008) “Targeting Selenium metabolism in Stickland fermentors: Novel Narrow Spectrum Antimicrobial Drug Development” Anaerobes 2008: Ninth Biennial Congress of the Anaerobe Society of the Americas, Long Beach, California, June 24-27, 2008.
S.E. Jackson-Rosario* and W. T. Self (2008) “Interruption of Selenium metabolism: A Novel pathway for Antimicrobial Development” Annual meeting of the Florida Branch of the American Society for Microbiology, Jacksonville, Florida, November 8th-9th.
S.E. Jackson-Rosario, R. Tarrien, C. Korsvik, and W. T. Self* (2008)
“Selenium Availability Influences the Antimicrobial Action of Stannous Salts Against Treponema denticola” 108th General Meeting of the American Society for Microbiology (ASM), Boston, Massachusetts, June 1-5, 2008. Poster K-053.
S.E. Jackson*, A. Myers, R. Tarrien and W. T. Self (2007) “Auranofin interferes with Selenium metabolism in Clostridium difficile” Florida Branch ASM meeting, St. Petersburg, Florida, October 6-8th.
S.E. Jackson*, A. Myers, R. Tarrien and W. T. Self (2007) “Auranofin interferes with Selenium metabolism in Clostridium difficile” Interscience Conference on Antimicrobial Agents and Chemotherapy, (ICAAC 2007), Chicago, Illinois. Student received a $500 competitive travel award
A. Myers*, S.E. Jackson, R. Tarrien, W.T. Self (2007) “Inhibition of Clostridium difficile growth by proline derivatives and gold compounds” SURE 2007- Showcase of Undergraduate Research, April 6th, University of Central Florida, Orlando, Florida.
S.E. Jackson*, Mary Calos, A. Myers and W.T. Self (2006) “Selenoproteins in Clostridium difficile: A role in pathogenesis” Selenium 2006. 8th International Symposium on Selenium in Biology and Medicine, Madison, Wisconsin.
D. Ganyc*, S. Talbot, S.E. Jackson and W.T. Self (2006) “Effects of trivalent arsenicals on selenium metabolism in (HaCaT) skin cell model” Selenium 2006. 8th International Symposium on Selenium in Biology and Medicine, Madison, Wisconsin.
S. Talbot*, D. Ganyc, S.E. Jackson and W.T. Self (2006) “Arsenite Inhibits Selenoprotein Synthesis in a Lung Cell Model.” Selenium 2006. 8th International Symposium on Selenium in Biology and Medicine, Madison, Wisconsin.
S. E. Jackson*, A. Myers and W.T. Self (2006) “The effect of Stickland acceptors on toxin regulation in Clostridium difficile” ASM General Meeting, Orlando, Florida.
S.E. Jackson*, A. Myers and W.T. Self (2006) “The effect of Stickland acceptors on toxin regulation in Clostridium difficile” Florida Branch ASM (Oral Presentation), Cocoa Beach, Florida.
S.E. Jackson*, M. Calos, A. Myers, and W.T. Self (2006) “Stickland reactions in Clostridium difficile:: A role in pathogenesis?” UCF Burnett College of Biomedical Sciences Graduate Symposium (Oral Presentation)
S.E. Jackson, M. Calos and W.T. Self* (2005) Stickland Reactions and Toxin Production in Clostridium difficile. IUMS 2005- International Congress of Bacteriology and Applied Microbiology, San Francisco, California.
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Links
American Society for Cell Biology
American Society for Microbiology
Centers for Disease Control and Prevention
Microbe World
World Health Organization:WHO
